Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Pituitary extracts—especially those derived from the anterior pituitary—have played a significant role in the scientific management of infertility, particularly before the advent of recombinant hormone therapies. The pituitary gland produces key hormones such as follicle-stimulating hormone (FSH) and luteinizing hormone (LH), both of which are central to the regulation of ovulation and spermatogenesis. Early fertility treatments in the mid-20th century utilized pituitary extracts from human cadavers (hMG, or human menopausal gonadotropin, also known as Pergonal), administered to stimulate ovulation in women with hypogonadotropic hypogonadism or certain forms of anovulation. These treatments were shown in clinical studies to induce ovulation and support pregnancy, providing a scientific foundation for their use.

However, with the development of highly purified and recombinant versions of FSH and LH, the use of crude or semi-purified pituitary extracts has largely been replaced due to safety, efficacy, and ethical concerns. There is extensive scientific literature documenting the efficacy of pituitary-derived gonadotropins for treating infertility. Historical evidence is robust, and the mechanism is well understood. Thus, while modern fertility treatments use more refined forms of these hormones, the use of pituitary extracts to treat infertility is scientifically validated based on their physiological role and decades of clinical experience.

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