Evidence supporting the use of: Iron
For the health condition: Infertility

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Iron is scientifically validated as an important nutrient in the support and treatment of certain types of infertility, particularly those related to iron deficiency anemia. Iron plays a crucial role in several physiological processes, including oxygen transport, DNA synthesis, and cellular energy production—all of which are important for normal reproductive function. Numerous studies have shown that iron deficiency can lead to ovulatory dysfunction, anovulation, and reduced fertility in women. For example, research from the Nurses’ Health Study II found that women who consumed iron supplements had a significantly reduced risk of ovulatory infertility compared to those who did not. Iron supplementation is especially relevant for women who have heavy menstrual bleeding, are pregnant or planning pregnancy, or have diagnosed anemia, conditions that are known to reduce iron stores and potentially impact fertility.

The scientific evidence supporting iron supplementation for improving fertility is strongest in women with documented iron deficiency or anemia, rather than the general population. In men, the evidence is less robust, but iron deficiency can still contribute to poor overall health, which may indirectly impact reproductive health. Guidelines from medical organizations often recommend assessing and correcting iron deficiency as part of preconception care. In summary, while iron is not a “fertility drug,” its role in treating infertility associated with iron deficiency is well-established and scientifically supported.

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