Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Aucubin is an iridoid glycoside found in several medicinal plants, such as Plantago species and Aucuba japonica. Traditionally, these plants have been used in herbal medicine systems—particularly in Europe and Asia—for their purported anti-inflammatory, antimicrobial, and wound-healing properties. The historical use of Plantago major (plantain) leaves, rich in aucubin, includes topical and oral treatments for infections, including those believed to be caused by viruses, such as colds and flu-like illnesses. However, direct traditional references specifically isolating aucubin for viral infections are rare; most references pertain to the whole plant extracts. From a scientific perspective, some in vitro studies suggest that aucubin possesses antiviral activity against certain viruses, such as hepatitis B and herpes simplex virus. However, these studies are limited in scope, often preliminary, and rarely translated into in vivo (animal or human) research. There is currently insufficient clinical evidence to support the efficacy of aucubin or aucubin-containing extracts in treating or preventing viral infections in humans. Thus, while there is a historical basis for using aucubin-containing plants in the context of infections, robust scientific validation is lacking, and the evidence is best characterized as traditional with a low to moderate strength (rated 2 out of 5).

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