Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pediococcus acidilactici is a lactic acid bacterium that has been studied for its probiotic effects, including its potential to help prevent or manage bacterial infections. The scientific justification for its use centers around its ability to modulate the gut microbiota, enhance the intestinal barrier, and produce antimicrobial substances such as bacteriocins (e.g., pediocin), which can inhibit the growth of pathogenic bacteria. Several in vitro and animal studies have demonstrated that P. acidilactici can suppress the proliferation of pathogenic bacteria like Salmonella and Escherichia coli in the gastrointestinal tract. Moreover, some small human studies and clinical trials suggest potential benefits in reducing infection rates, particularly in the context of gastrointestinal infections, although robust clinical evidence is limited.

Despite these promising findings, the overall quality and quantity of clinical trials involving P. acidilactici for treating or preventing bacterial infections in humans remains low. Most evidence comes from laboratory or animal studies, and only a few human studies have been conducted, often with small sample sizes and varying designs. Therefore, while there is a scientific rationale and some preliminary evidence supporting its use against bacterial infections, more high-quality, large-scale clinical trials are needed to establish clear efficacy and guidelines for use.

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