Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Mannose is a simple sugar that has been studied for its role in preventing and supporting treatment of certain bacterial infections, most notably urinary tract infections (UTIs) caused by Escherichia coli. The scientific rationale is that mannose can bind to the bacterial lectins (specifically FimH adhesins) on the surface of uropathogenic E. coli, thereby preventing the bacteria from adhering to the urothelial cells lining the urinary tract. This anti-adhesive mechanism reduces the ability of bacteria to colonize and cause infection.

Several clinical studies and randomized controlled trials have evaluated the effectiveness of D-mannose in the prevention of recurrent UTIs, particularly in women. Some studies suggest that D-mannose supplementation may be as effective as prophylactic antibiotics in reducing UTI recurrence, with fewer side effects. However, the quality and size of these studies vary, and while results are promising, they are not universally conclusive. The use of mannose for other types of bacterial infections lacks substantial evidence.

Overall, there is a moderate level of scientific validation for mannose in the prevention (and to a lesser extent, treatment) of uncomplicated UTIs caused by E. coli. Its efficacy for other types of bacterial infections is not well-supported. Thus, the evidence rating for its use in bacterial infection (specifically UTIs) is 3 out of 5.

More about Mannose
More about Infection (bacterial)

Other ingredients used for Infection (bacterial)

Other health conditions supported by Mannose

Products containing Mannose