Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus gasseri is a probiotic bacterium that has been investigated for its potential to support or treat bacterial infections, particularly in the gastrointestinal and urogenital tracts. The scientific rationale for its use is based on its ability to compete with pathogenic bacteria for adhesion sites on mucosal surfaces, produce lactic acid and other antimicrobial compounds (such as bacteriocins), and modulate host immune responses. Several in vitro and animal studies have demonstrated that L. gasseri can inhibit the growth of pathogens including Helicobacter pylori, Escherichia coli, and Gardnerella vaginalis. Small-scale human trials have suggested potential benefits in reducing the incidence or severity of bacterial vaginosis and urinary tract infections, as well as supporting eradication of H. pylori when used as an adjunct to standard therapy.

However, the overall clinical evidence remains limited, with most studies being relatively small and varying in methodology and outcome measures. Meta-analyses and reviews indicate a possible role for L. gasseri as a supportive therapy, but not as a replacement for conventional antibiotics. More robust, large-scale randomized controlled trials are needed to confirm its efficacy and to establish optimal dosing and strains. Thus, while there is some scientific validation for the use of L. gasseri in preventing or managing certain bacterial infections, the strength of the evidence is moderate at best, warranting a rating of 2 out of 5.

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