Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lactobacillus crispatus is a prominent member of the normal vaginal microbiota and is widely studied for its role in supporting vaginal health and reducing the risk of bacterial infections, especially bacterial vaginosis (BV). Scientific evidence indicates that L. crispatus helps maintain a healthy vaginal environment by producing lactic acid and hydrogen peroxide, which lower vaginal pH and inhibit the growth of pathogenic bacteria such as Gardnerella vaginalis and other BV-associated organisms.

Clinical studies have shown that women with a vaginal microbiota dominated by L. crispatus are less likely to develop BV and have lower recurrence rates after treatment. For example, a 2019 randomized controlled trial demonstrated that vaginal administration of L. crispatus after antibiotic treatment for BV significantly reduced recurrence rates compared to placebo. Additionally, observational studies support the correlation between the presence of L. crispatus and a reduced incidence of sexually transmitted infections (STIs).

While the overall evidence base is growing, large-scale, long-term studies are still needed to confirm the most effective strains, formulations, and delivery methods. Nevertheless, the use of L. crispatus as a probiotic for supporting vaginal health and preventing or treating bacterial infections is supported by moderate scientific evidence, with increasing clinical validation in recent years.

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