Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Isoalantolactone is a sesquiterpene lactone found in plants such as Inula helenium (elecampane). There is some scientific evidence suggesting that isoalantolactone possesses antibacterial activity. In vitro studies have demonstrated that isoalantolactone can inhibit the growth of several bacterial strains, including both Gram-positive and Gram-negative bacteria. For example, research has shown that isoalantolactone exhibits inhibitory effects against Staphylococcus aureus and Escherichia coli, possibly by disrupting bacterial cell membrane integrity or interfering with biofilm formation. These effects have been observed at the cellular and molecular levels in laboratory experiments.

However, evidence is limited to preclinical studies, primarily in vitro, and there is a lack of clinical trials or robust animal studies to confirm its efficacy or safety in treating bacterial infections in humans. While traditional use of elecampane root (which contains isoalantolactone) for respiratory infections is documented in herbal medicine, the specific contribution of isoalantolactone itself has not been firmly established in clinical settings. Thus, while there is some scientific basis for its antibacterial potential, the current evidence does not strongly support its use as a treatment for bacterial infections in humans.

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