Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Glycerol monolaureate (GML), also known as monolaurin, has demonstrated notable antimicrobial activity in scientific studies, particularly against a range of Gram-positive bacteria. Research indicates that GML disrupts the lipid membranes of bacteria, leading to cell lysis and death. Several in vitro studies have shown that GML is effective against pathogens such as Staphylococcus aureus, Streptococcus species, and Clostridium species. Some animal model research also supports its potential role in reducing the severity or incidence of bacterial infection, and it has been investigated for use in topical formulations to prevent bacterial colonization and infection.

However, the majority of evidence remains preclinical, and there are currently limited clinical trials in humans directly evaluating GML’s efficacy in treating or preventing bacterial infections. While GML is generally recognized as safe and is used in foods and cosmetics, its use as a therapeutic agent for bacterial infections in humans is not yet established in clinical practice. The promising laboratory and animal data justify further investigation, but currently, GML cannot be recommended as a standalone treatment for bacterial infections based on existing evidence. Thus, the evidence supporting its use is moderate, with scientific rationale but insufficient clinical validation.

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