Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bisabolol, a naturally occurring monocyclic sesquiterpene alcohol found in chamomile (Matricaria chamomilla) and other plants, has been investigated for its antimicrobial properties, including activity against certain bacterial pathogens. Several in vitro studies have demonstrated that bisabolol possesses moderate antibacterial activity, particularly against Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes. The mechanism is believed to involve disruption of bacterial cell membranes, leading to cell lysis and death. Additionally, bisabolol has anti-inflammatory and skin-soothing effects, making it a common ingredient in topical formulations for skin care and wound healing.

However, while laboratory studies support bisabolol’s antibacterial potential, clinical evidence for its use in treating or preventing bacterial infections in humans is limited. Most data comes from in vitro assays, with few clinical trials assessing its efficacy as a stand-alone antimicrobial treatment. Instead, bisabolol is more commonly used as an adjunct in topical products, where its mild antimicrobial activity may contribute to infection prevention alongside other ingredients. In summary, there is scientific evidence for bisabolol’s antibacterial properties, but the strength of evidence for its use in clinical infection management is currently modest (rated 2/5), pending further clinical research.

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