Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bacillus subtilis is a spore-forming probiotic bacterium that has been investigated for its potential to support or treat bacterial infections, primarily by modulating the gut microbiota and enhancing host immune responses. The scientific evidence supporting its use is modest but growing. Preclinical studies have demonstrated that B. subtilis can inhibit pathogenic bacteria (such as Salmonella, Staphylococcus aureus, and Clostridium difficile) by producing antimicrobial compounds (bacteriocins) and by competitive exclusion in the gut environment. Some animal studies have shown that supplementation with B. subtilis reduces the severity or incidence of infections, particularly in livestock and poultry, leading to its use in veterinary medicine as a feed additive to reduce antibiotic reliance.

In humans, the evidence is less robust. A few small clinical trials and pilot studies suggest B. subtilis may help restore gut microbiota after antibiotic use and reduce risk of Clostridium difficile infection, but high-quality randomized controlled trials are limited. The ability of B. subtilis to directly treat active bacterial infections in humans is not well established. Most clinical use focuses on supporting gut health and potentially preventing infection rather than treating established disease. The overall evidence base is promising but not definitive, warranting a moderate rating of 2 out of 5 for scientific support in the context of infection treatment or prevention.

More about bacillus subtilis
More about Infection (bacterial)

Other ingredients used for Infection (bacterial)

Other health conditions supported by bacillus subtilis

Products containing bacillus subtilis

Nature's Sunshine AIVIA Performance Probiotic