Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Bacillus species, particularly Bacillus subtilis, Bacillus clausii, and other mixed Bacillus probiotics, are used to support the management of bacterial infections, especially those affecting the gastrointestinal tract. Scientific evidence suggests that certain Bacillus strains can help restore and maintain healthy gut microbiota, inhibit the growth of pathogenic bacteria, and modulate the immune response. Several clinical studies have investigated Bacillus clausii as an adjunct therapy in children and adults with acute diarrhea, some of which are caused by bacterial infections. These studies reported reduced duration and severity of diarrhea and improved recovery, likely due to the competitive exclusion of pathogens and the production of antimicrobial substances (bacteriocins) by Bacillus strains.

However, the evidence is largely limited to mild and self-limiting gastrointestinal infections; Bacillus probiotics are not considered a primary treatment for systemic or severe bacterial infections. The mechanism involves both direct antagonism of pathogens and support of mucosal immunity. Meta-analyses and randomized controlled trials (RCTs) generally support a moderate benefit for Bacillus supplementation as an adjunct in infectious diarrhea, but the data quality and consistency vary. Thus, while there is scientific validation for the use of Bacillus (mixed) in the supportive management of some bacterial infections—primarily gastrointestinal—the evidence does not support its use as a substitute for standard antibiotic therapy in serious infections.

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