Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Several species within the genus Polygonum (commonly called knotweed) have a long history of use in traditional medicine systems, including Traditional Chinese Medicine (TCM), Ayurveda, and various folk medicines. In these practices, different Polygonum species such as Polygonum cuspidatum (Japanese knotweed) and Polygonum aviculare (common knotgrass) have been employed for their purported antibacterial, antiviral, and anti-inflammatory properties. Preparations made from Polygonum are often used to address infections of the respiratory, urinary, and digestive tracts, among others. The rationale for their use is typically based on empirical tradition and anecdotal reports rather than rigorous scientific validation.

While some laboratory studies have identified antimicrobial compounds (such as resveratrol in P. cuspidatum), the bulk of clinical evidence supporting the use of Polygonum species against infections in humans is lacking or limited to preliminary studies. Thus, the justification for using unspecified Polygonum species to support or treat infections is primarily rooted in tradition, with moderate historical evidence but only limited and indirect scientific support at this time.

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