Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Immunoglobulin G (IgG) is justified for use in treating or supporting infections based on strong scientific evidence. IgG is the most abundant antibody in human serum and plays a critical role in immune defense by neutralizing pathogens and facilitating their clearance. Therapeutically, intravenous immunoglobulin (IVIG), which is a purified IgG preparation from pooled plasma donors, is used to treat a variety of infectious diseases and immunodeficiency states. In patients with primary or secondary antibody deficiencies, IVIG provides passive immunity, reducing the frequency and severity of infections. Clinical trials and extensive observational studies have demonstrated that IVIG replacement significantly decreases the risk of serious bacterial infections in these populations.

Beyond replacement therapy, IVIG has also been used as adjunctive treatment in severe infections such as Kawasaki disease, toxic shock syndrome, and necrotizing fasciitis, where its immunomodulatory properties are thought to help mitigate harmful inflammatory responses. Guidelines from organizations such as the World Health Organization and the Infectious Diseases Society of America support the use of IgG for specific infectious indications. However, IVIG is not recommended for general prophylaxis in immunocompetent individuals due to cost, supply limitations, and risk of adverse effects. Overall, the use of IgG in infection is grounded in robust clinical evidence and widespread clinical practice.

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