Evidence supporting the use of: Goldenseal
For the health condition: Infection

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Goldenseal (Hydrastis canadensis) has a long history of traditional use among Native American tribes and later in Western herbalism, primarily as a remedy for infections and inflammation. Its use for infections is mainly attributed to its content of alkaloids, particularly berberine, which has demonstrated antimicrobial activity in laboratory studies. Historically, goldenseal was used for a variety of ailments, including respiratory, digestive, and urinary tract infections, as well as for wound healing. However, while in vitro (test tube) studies have shown that berberine and related compounds possess antibacterial and antifungal properties, there is limited direct clinical evidence supporting the effectiveness of goldenseal as a treatment for infections in humans.

Most of the support for goldenseal’s use in infection comes from traditional and anecdotal sources rather than rigorous scientific research. A few small studies and case reports suggest potential benefits, but these are insufficient to establish goldenseal as an evidence-based treatment for infections. Furthermore, concerns exist regarding its safety and potential for drug interactions, especially when used in large amounts or over extended periods. In summary, goldenseal's use for infection is primarily rooted in tradition, with limited scientific validation, justifying a modest evidence rating.

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