Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Globulins are a group of proteins in the blood, including immunoglobulins (antibodies), which play a critical role in the immune response. The therapeutic use of globulins, most commonly as intravenous immunoglobulin (IVIG), is well-established in the treatment and prevention of certain infections, especially in patients with primary or secondary immunodeficiencies. Scientific validation comes from numerous clinical trials and decades of clinical practice where IVIG has been shown to reduce the frequency and severity of infections in patients who cannot produce adequate antibodies themselves (e.g., congenital agammaglobulinemia, common variable immunodeficiency). In addition, IVIG is used as post-exposure prophylaxis for specific infections (such as hepatitis B, rabies, and varicella) when immediate passive immunity is required.

The mechanism of action is the provision of functional antibodies that can recognize and neutralize pathogens, thereby supporting or replacing the patient's deficient immune response. The efficacy and safety of immunoglobulin therapy have been confirmed in guidelines and systematic reviews. However, globulin preparations are not used to treat all infections—rather, their use is targeted to situations where antibody deficiency or the need for immediate antibody-mediated immunity is present.

Therefore, the use of globulins (particularly immunoglobulins) to prevent or treat infections is supported by strong scientific evidence in specific clinical contexts, but not as a general treatment for all infections.

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