Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Benzyl isothiocyanate (BITC) is a naturally occurring compound found in cruciferous vegetables such as mustard, cabbage, and garden cress. Its use in the context of infection is primarily supported by laboratory and preclinical studies. BITC has demonstrated notable antimicrobial activity in vitro against a variety of bacterial and fungal pathogens. Mechanistically, it is believed to disrupt microbial cell membranes, inhibit essential enzymes, and induce oxidative stress within microbial cells. Several studies have highlighted its effectiveness against common pathogens such as Staphylococcus aureus, Escherichia coli, and Candida albicans. Some research also suggests synergistic effects when BITC is combined with conventional antibiotics, potentially enhancing antimicrobial efficacy and overcoming resistance.

However, the current evidence is largely restricted to in vitro experiments and animal models. There is a lack of well-controlled human clinical trials evaluating the efficacy and safety of BITC for treating infections. As such, while the scientific rationale and laboratory data are promising, clinical validation is lacking. Therefore, BITC cannot yet be recommended as a standalone or primary treatment for infections in humans, though it remains a compound of interest for future antimicrobial drug development.

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