Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Bacillus clausii is a probiotic bacterium that has been investigated for its role in supporting and treating certain infections, particularly those involving the gastrointestinal tract. Its primary use is as an adjunct in the management of antibiotic-associated diarrhea and in the support of gut microbiota during or after antibiotic therapy. Several randomized controlled trials and systematic reviews suggest that Bacillus clausii can reduce the incidence and duration of diarrhea associated with antibiotics and may help restore gut flora balance. Its mechanism of action includes production of antimicrobial substances, competitive inhibition of pathogenic bacteria, and modulation of the immune response.

While most of the evidence pertains to gastrointestinal infections, there is less support for its use in treating systemic or non-gut infections. Nonetheless, Bacillus clausii’s ability to survive gastric acidity and to sporulate makes it particularly resilient as a probiotic supplement. Its safety profile is favorable, with few adverse events reported in clinical trials. The majority of scientific validation comes from studies conducted in children and adults suffering from diarrhea due to antibiotics or infectious agents. However, more well-designed, large-scale studies are needed to provide high-level evidence (levels 4-5) for broader infectious indications.

In summary, there is moderate scientific evidence supporting the use of Bacillus clausii for preventing and managing certain GI infections, especially antibiotic-associated diarrhea (evidence rating: 3/5), but it should not be considered a primary treatment for severe or systemic infections.

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