Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Bacillus species, particularly Bacillus subtilis and Bacillus clausii, have been studied for their probiotic effects in supporting and treating infections, especially those related to the gastrointestinal tract. Bacillus-based probiotics are spore-forming bacteria that are resistant to harsh environmental conditions, allowing them to survive stomach acidity and reach the intestines, where they may exert beneficial effects. Scientific studies indicate that certain Bacillus strains can inhibit the growth of pathogenic bacteria through the production of antimicrobial compounds (such as bacteriocins and lipopeptides) and by competitive exclusion. Clinical trials, especially with Bacillus clausii, have demonstrated some benefit in reducing the duration and severity of antibiotic-associated diarrhea and acute infectious diarrhea in children and adults. For example, randomized controlled trials have shown that Bacillus clausii supplementation can decrease the duration of diarrhea caused by infections.

However, while the evidence is promising, it is not universally strong across all types of infections, and the majority of rigorous studies focus on gastrointestinal infection or antibiotic-associated conditions rather than systemic infections. The overall evidence base is moderate (rating: 3), with most benefits observed in the context of gut health and infection prevention or mitigation. More research is needed to fully characterize the efficacy for broader infectious indications and to determine the effectiveness of individual Bacillus strains.

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