Babchi (Psoralea corylifolia) has a long history of use in traditional Ayurvedic and Chinese medicine, particularly for skin-related infections and disorders. Traditionally, Babchi seeds and their extracts have been used topically to address various skin infections such as ringworm, leprosy, and vitiligo, primarily due to their purported antimicrobial properties. The main active compound, psoralen, is believed to contribute to these effects. Historical texts and ethnobotanical reports describe its application as a poultice or oil for infectious skin conditions, with practitioners attributing its effectiveness to both antibacterial and antifungal actions.

Scientifically, preliminary in vitro studies have demonstrated that Babchi extracts possess some degree of antibacterial and antifungal activity against certain pathogens, such as Staphylococcus aureus and Candida albicans. However, robust clinical trials validating its efficacy for treating infections in humans are lacking. Most of the available evidence remains preclinical or anecdotal, and concerns about potential toxicity (especially phototoxicity due to psoralens) limit its widespread clinical use. Thus, while traditional use for infections is well-documented and supported by some laboratory research, high-quality human data are insufficient, justifying a moderate evidence rating.