Synopsis

Source of validity: Traditional
Rating (out of 5): 1

American Liverleaf (Hepatica americana), also known as Hepatica or Liverwort, has a history of use in traditional Native American and early European herbal medicine. It was primarily used as a remedy for liver ailments, but it was also sometimes applied for respiratory infections, coughs, and general infections, based on the doctrine of signatures (the belief that plants resembling certain organs could treat ailments of those organs). However, scientific research on Hepatica’s antimicrobial or infection-fighting properties is extremely limited. There are no well-conducted clinical trials or robust preclinical studies that validate its efficacy against infections. Most modern herbal references mention its use for infections only in the context of historical practice, not scientific validation. Therefore, the use of American Liverleaf for supporting or treating infections is justified mainly by tradition, with little to no scientific backing, and the evidence supporting this practice is very weak.

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