Lactobacillus species are commonly used as probiotics and have been investigated for their potential benefits in digestive health, including the management of indigestion (also known as dyspepsia). The scientific evidence supporting the use of unspecified Lactobacillus for indigestion is modest. Some clinical trials and meta-analyses suggest that probiotics, including Lactobacillus strains, may help reduce certain gastrointestinal symptoms such as bloating, abdominal discomfort, and irregular bowel movements, all of which may contribute to the sensation of indigestion. However, most studies involve mixed probiotic formulations or focus on specific Lactobacillus strains, not unspecified or generic Lactobacillus.

The mechanisms proposed include modulation of gut microbiota, enhancement of mucosal barrier function, and reduction of low-grade inflammation in the gastrointestinal tract. Nevertheless, the evidence remains inconsistent, with some studies showing no significant benefit over placebo, especially when "indigestion" is defined broadly or not clearly distinguished from other gastrointestinal disorders like irritable bowel syndrome (IBS) or functional dyspepsia. Additionally, the lack of strain-specific data makes it difficult to draw firm conclusions about the efficacy of unspecified Lactobacillus for indigestion.

Overall, while there is some scientific rationale and preliminary clinical support, the evidence is not robust, and more high-quality, strain-specific studies are needed to confirm efficacy. As such, the use of Lactobacillus for indigestion can be considered scientifically plausible but not strongly validated.