Enzyme blends, typically containing digestive enzymes such as amylase, protease, and lipase, are commonly used to support or treat indigestion (also known as dyspepsia). The scientific rationale behind this use is that digestive enzymes help break down macronutrients—carbohydrates, proteins, and fats—into smaller molecules for absorption in the gastrointestinal tract. In cases where the body does not produce sufficient digestive enzymes (for example, in pancreatic insufficiency), supplementation can alleviate symptoms like bloating, gas, and discomfort after eating.

Clinical trials and systematic reviews provide moderate evidence supporting the use of prescription pancreatic enzyme supplements in conditions like chronic pancreatitis and cystic fibrosis, which are characterized by enzyme deficiency. There is also emerging, though less robust, evidence that over-the-counter enzyme blends may help relieve mild indigestion in otherwise healthy individuals, especially after high-fat meals. However, the evidence is inconsistent, and not all studies show benefit for general dyspepsia unrelated to enzyme deficiency.

Overall, while the use of enzyme blends for indigestion has a scientific basis—particularly for specific medical conditions involving enzyme deficiency—evidence for their effectiveness in the general population with functional dyspepsia is moderate but not definitive. More high-quality, large-scale trials are needed to confirm benefits for the broader population.