Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Bicarbonate (mixed), typically referring to sodium bicarbonate or a combination of alkali salts, is scientifically validated for the treatment of indigestion, specifically for symptoms related to acid reflux and heartburn. Bicarbonate acts as a systemic antacid by neutralizing excess gastric acid in the stomach, thus providing rapid relief from the burning sensation and discomfort associated with indigestion (dyspepsia). Numerous clinical studies and pharmacological references, including the British National Formulary and Goodman & Gilman's The Pharmacological Basis of Therapeutics, recognize sodium bicarbonate as an effective, fast-acting antacid.

The mechanism is straightforward: bicarbonate ions react with hydrochloric acid (HCl) in the stomach to produce water and carbon dioxide, thereby reducing gastric acidity. However, its use is best suited for short-term relief due to potential risks such as metabolic alkalosis, sodium overload, and rebound acid hypersecretion with frequent or prolonged use.

Historically, bicarbonate of soda has been used as a home remedy for indigestion for over a century, but this traditional use has been validated by medical science. Modern over-the-counter antacid preparations often include bicarbonate as an active ingredient. Clinical guidelines support its use for acute, occasional symptoms but recommend caution in patients with underlying cardiovascular, renal, or hepatic conditions due to its sodium content. In summary, bicarbonate’s use for indigestion is grounded in both scientific evidence and longstanding practice.

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