Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Aspergillus niger is a filamentous fungus commonly used in the production of industrial enzymes, including those that aid in digestion such as amylase, protease, and lipase. The use of Aspergillus niger-derived enzymes in digestive enzyme supplements is supported by scientific literature, but the evidence is moderate and primarily indirect. These enzyme preparations, often labeled as “Aspergillus niger fermentation products,” are used to supplement the body’s natural digestive enzymes and may help break down carbohydrates, proteins, and fats in individuals with enzyme insufficiencies (e.g., pancreatic insufficiency, certain malabsorption syndromes).

A handful of clinical trials and reviews have examined the effectiveness of fungal-derived enzyme blends (including those from Aspergillus niger) for improving symptoms of indigestion, such as bloating, gas, and discomfort. Some studies show statistically significant improvements in digestive symptoms compared to placebo, but methodological weaknesses and small sample sizes limit the strength of these conclusions. The US Food and Drug Administration (FDA) recognizes certain Aspergillus niger enzymes as Generally Recognized As Safe (GRAS) for use in food processing and supplements.

In summary, while the direct scientific evidence supporting Aspergillus niger-derived enzymes for the treatment of indigestion is limited and not robust, there is a plausible rationale and some supportive data, especially for people with specific enzyme deficiencies. Thus, the use is primarily justified by scientific reasoning, but the strength of clinical evidence is moderate (rated 2/5).

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