Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Amylase (gamma) is an enzyme involved in the breakdown of carbohydrates, specifically starches, into simpler sugars that can be absorbed in the digestive tract. The use of amylase, including gamma-amylase, to support or treat indigestion is primarily justified by scientific rationale, though the direct clinical evidence is moderate rather than robust. Digestive enzyme supplements, including amylase, have been shown in some clinical studies to help improve symptoms of indigestion (dyspepsia), especially in people with pancreatic insufficiency or those who produce insufficient digestive enzymes. Amylase supplementation can assist in carbohydrate digestion, potentially reducing feelings of fullness, bloating, or discomfort associated with undigested starches in the gut.

However, most research focuses on general digestive enzyme blends rather than isolated gamma-amylase. The evidence for efficacy is strongest in individuals with enzyme deficiencies; benefits for the general population with functional indigestion are less certain. The theoretical basis is solid, as amylase is a natural component of human saliva and pancreatic juice, but large, high-quality clinical trials specifically evaluating gamma-amylase for indigestion are lacking. In summary, the use of amylase for indigestion has scientific support grounded in enzyme physiology and some clinical research, but the evidence base is not extensive and does not specifically emphasize gamma-amylase.

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