Evidence supporting the use of: Selenium Yeast
For the health condition: Hypothyroid

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Selenium yeast is a well-absorbed organic form of selenium commonly used as a dietary supplement. The use of selenium to support thyroid function, particularly in cases of hypothyroidism, is supported by scientific evidence. Selenium is an essential trace element involved in the synthesis and activity of selenoproteins, some of which are critical for thyroid hormone metabolism and protection of thyroid cells from oxidative damage. Specifically, the enzymes iodothyronine deiodinases, which convert the thyroid hormone thyroxine (T4) to its active form triiodothyronine (T3), require selenium for their activity.

Clinical studies indicate that selenium supplementation, including selenium yeast, may be beneficial in autoimmune thyroiditis (Hashimoto’s thyroiditis), which is a common cause of hypothyroidism. Meta-analyses and randomized controlled trials have demonstrated that selenium supplementation can reduce thyroid peroxidase antibody (TPOAb) levels and may improve the inflammatory status of the thyroid gland. However, the impact on thyroid hormone levels and clinical symptoms is less consistent, and the benefit is most pronounced in selenium-deficient populations.

While selenium yeast is not a primary treatment for hypothyroidism, it is justified as an adjunctive support, particularly in individuals with low selenium status or autoimmune thyroiditis. Care should be taken to avoid excess selenium intake, as toxicity is possible at high doses. Overall, scientific evidence supports its use as a supportive measure, though not as a stand-alone therapy for hypothyroidism.

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