Evidence supporting the use of: D-Aspartic Acid
For the body system: Hypothalamus

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

D-Aspartic Acid (DAA) is an amino acid that has gained attention for its potential role in supporting the hypothalamus and related endocrine functions, particularly regarding its influence on the hypothalamic-pituitary-gonadal (HPG) axis. Scientific studies, primarily in animals and some in humans, have shown that DAA is present in neuroendocrine tissues, including the hypothalamus, and may help regulate the synthesis and release of hormones such as gonadotropin-releasing hormone (GnRH). Some early research in rodents has demonstrated that administration of DAA can increase the expression of GnRH in the hypothalamus, potentially leading to elevated luteinizing hormone (LH) and testosterone production downstream. Human studies, however, provide mixed results. While a few small trials have reported modest increases in LH and testosterone after DAA supplementation in men, particularly those with low baseline testosterone, other studies have found no significant effect in healthy, resistance-trained men. The evidence supporting DAA as a supplement for hypothalamic support is therefore limited and inconsistent, with most research focusing on reproductive hormone modulation rather than broader hypothalamic health. Overall, while there is a plausible biological mechanism and some scientific investigation into DAA’s effects on the hypothalamus, the clinical evidence is not robust. More large-scale, well-controlled human studies are needed to substantiate its use for hypothalamic support or hormonal balance.

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