Evidence supporting the use of: Agnusides
For the body system: Hypothalamus

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Agnusides are iridoid glycosides found primarily in the fruit of Vitex agnus-castus (chaste tree). The traditional use of Vitex agnus-castus dates back to ancient Greece and Rome, where it was employed to address various female reproductive concerns, particularly menstrual irregularities and premenstrual syndrome (PMS). The rationale for its use is rooted in anecdotal evidence and historical herbal medicine practices, where it was believed to "balance" hormones and support the female endocrine system.

While there is some modern evidence suggesting Vitex agnus-castus may benefit reproductive hormone balance, most research focuses on its effect on the pituitary gland—specifically, modulation of prolactin secretion—rather than direct action on the hypothalamus itself. Agnusides are considered one of the active components, but specific data on agnusides and direct support of hypothalamic function are lacking. Thus, the connection to hypothalamus support is largely based on historical tradition rather than robust scientific validation. Clinical studies with Vitex extracts (not isolated agnusides) show some promise for PMS and cycle regulation, but the direct impact on hypothalamic health or function is not well-established in the scientific literature.

In summary, the use of agnusides to support the hypothalamus is primarily traditional, with limited direct scientific evidence specific to this body system.

More about Agnusides
More about Hypothalamus

Products containing Agnusides

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