Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Adrenaline (also known as epinephrine) is scientifically validated for the treatment of hypotension, particularly in acute and emergency settings. Adrenaline is a potent catecholamine with alpha- and beta-adrenergic agonist activity. Its use is standard in advanced cardiac life support (ACLS) protocols for anaphylactic shock, severe hypotension, and cardiac arrest. Adrenaline increases blood pressure primarily through vasoconstriction (alpha-1 stimulation), increased cardiac contractility and heart rate (beta-1 stimulation), and bronchodilation (beta-2 stimulation). Clinical trials, guidelines (such as those from the American Heart Association), and decades of clinical experience support its efficacy and safety in acute hypotensive emergencies. For example, in anaphylactic shock, adrenaline is the first-line treatment because it can rapidly reverse vasodilation and airway compromise. In septic or other distributive shocks where hypotension is resistant to volume resuscitation, adrenaline is sometimes used as a vasopressor. However, for chronic hypotension, adrenaline is not typically indicated due to potential adverse effects and the availability of safer alternatives. Overall, the evidence base is robust, and its use in acute hypotension is an established medical practice with the highest level of scientific support.

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