Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Nitrates are scientifically validated for use in certain cardiovascular conditions, but their direct use for treating hypertension (high blood pressure) is more limited compared to other antihypertensive drugs. Nitrates, such as nitroglycerin and isosorbide dinitrate, primarily act as vasodilators: they relax the smooth muscles in blood vessel walls, leading to dilation of veins and, to a lesser extent, arteries. This results in decreased venous return to the heart, reduced cardiac preload, and, at high doses, a reduction in systemic vascular resistance, which can lower blood pressure. The most robust clinical evidence for nitrates is in the treatment of angina pectoris and acute heart failure, where reducing cardiac workload and improving oxygen delivery are paramount. In the context of hypertension, especially hypertensive emergencies or acute heart failure with elevated blood pressure, intravenous nitrates (like nitroglycerin) are used to rapidly reduce blood pressure and manage symptoms. However, for chronic management of hypertension, nitrates are not first-line therapy, as other drug classes (ACE inhibitors, ARBs, calcium channel blockers, and thiazide diuretics) have better evidence for reducing cardiovascular events. Nitrate therapy is also limited by the rapid development of tolerance. In summary, while nitrates have a clear, evidence-based role in acute settings where blood pressure must be lowered quickly, their use as routine antihypertensive agents is limited. The scientific evidence supporting their use for acute hypertension is strong, but for chronic blood pressure control, evidence is weaker and alternatives are preferred.

More about Nitrate
More about Hypertension

Other ingredients used for Hypertension

Other health conditions supported by Nitrate

Products containing Nitrate