Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Luteolin is a naturally occurring flavonoid found in various fruits, vegetables, and herbs. Its potential antihypertensive effects have been explored primarily in preclinical (animal and in vitro) studies. These studies suggest that luteolin may exert blood pressure-lowering effects through several mechanisms, including antioxidant activity, anti-inflammatory properties, and modulation of endothelial function. For example, luteolin has been shown to enhance nitric oxide (NO) production, leading to vasodilation and improved vascular health in animal models. Additionally, it may inhibit angiotensin-converting enzyme (ACE) activity and reduce oxidative stress in vascular tissues, both of which are relevant pathways in hypertension management.

However, the direct evidence supporting luteolin's use for hypertension in humans is limited. Most available data come from animal experiments or cell culture studies. There are very few, if any, robust clinical trials evaluating luteolin supplementation in human subjects with hypertension. Therefore, while there is a mechanistic rationale and promising preclinical data, clinical validation is lacking. Luteolin is not widely recognized in traditional medicine systems specifically for hypertension, and its use is not standard in evidence-based clinical practice for this condition.

In summary, the scientific evidence supporting luteolin for hypertension is preliminary (rated 2/5), based mainly on animal and mechanistic studies. Well-designed human clinical trials are needed before luteolin can be recommended as a treatment or supportive agent for hypertension.

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