Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ginsenosides, the primary active compounds in ginseng, have been traditionally used in East Asian medicine for a variety of ailments, including cardiovascular health. Modern scientific studies have investigated the effects of ginsenosides on hypertension (high blood pressure). Some preclinical (animal and in vitro) studies suggest that ginsenosides may exert antihypertensive effects by mechanisms such as vasodilation, improvement of endothelial function, and modulation of the renin-angiotensin system. For example, certain ginsenosides (such as Rg1 and Rb1) have been shown to relax blood vessels via nitric oxide pathways and calcium channel modulation in laboratory settings.

However, the clinical evidence in humans is limited and of low quality. Few randomized controlled trials have directly assessed the effect of purified ginsenosides or ginseng extracts on blood pressure in hypertensive patients. Some small studies report modest blood pressure reductions, but results are inconsistent, and methodological limitations (small sample sizes, lack of blinding, variable dosages and preparations) hinder strong conclusions. Systematic reviews and meta-analyses often note insufficient or inconclusive evidence regarding ginsenosides for hypertension.

In summary, while there is a scientific rationale and some preliminary evidence for the use of ginsenosides in supporting hypertension, the current level of clinical evidence is weak. More rigorous human studies are needed to confirm efficacy and safety for this indication.

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