Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Diallyl disulfide (DADS) is a sulfur-containing compound found in garlic (Allium sativum) and is considered one of the major bioactive components responsible for garlic’s health benefits. Scientific evidence supports its potential role in supporting or treating hypertension, though most studies are preclinical or in the early stages of human research. DADS has demonstrated vasodilatory effects in animal models, likely due to its interaction with endothelial nitric oxide pathways and its ability to modulate oxidative stress and inflammation. These mechanisms can lead to relaxation of blood vessels, resulting in lower blood pressure.

Some animal studies have shown that administration of DADS reduces systolic and diastolic blood pressure in hypertensive rats. In addition, research has indicated that DADS can inhibit angiotensin-converting enzyme (ACE) activity, which is a target of many conventional antihypertensive drugs. Human studies on garlic extracts (which contain DADS among other compounds) have reported modest reductions in blood pressure, but these studies rarely isolate the effect of DADS specifically.

Overall, while there are promising mechanistic and preclinical findings, clinical evidence directly linking DADS alone to antihypertensive effects is limited. Most human data comes from studies of whole garlic or garlic extracts, making it difficult to assign the effect solely to DADS. Thus, the evidence is rated moderate (3/5): there is a scientific rationale and some supporting data, but more high-quality human trials are needed for conclusive support.

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