Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Caffeoylquinic acids, particularly chlorogenic acid (the most common form), have been investigated for their potential antihypertensive effects. Some scientific studies—primarily small-scale human clinical trials and animal studies—suggest that chlorogenic acid may help lower blood pressure. The proposed mechanisms include improved endothelial function, inhibition of glucose absorption, and modulation of nitric oxide production, all of which can influence vascular tone and blood pressure. For instance, a randomized, double-blind, placebo-controlled trial published in Clinical and Experimental Hypertension (2006) demonstrated that daily intake of green coffee bean extract (standardized to chlorogenic acid) resulted in modest reductions in systolic and diastolic blood pressure in mildly hypertensive adults. Additional animal studies have reported similar effects, likely mediated by antioxidant actions and impacts on the renin-angiotensin system.

However, the overall quality and quantity of evidence remain limited. Most clinical trials to date have been small and of short duration, and there is a lack of large-scale, long-term studies confirming efficacy and safety. While caffeoylquinic acids do not have a strong tradition of use for hypertension in herbal medicine, current scientific interest is growing, but the evidence is still considered preliminary. Larger, well-designed studies are needed before caffeoylquinic acids can be recommended as a reliable treatment for hypertension.

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