Evidence supporting the use of: Red clover
For the health condition: Hot Flashes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Red clover (Trifolium pratense) has been traditionally used for various women’s health issues, including menopausal symptoms such as hot flashes. Its use for hot flashes is supported by the presence of isoflavones—phytoestrogens that are chemically similar to human estrogen. These compounds, notably biochanin A and formononetin, are thought to exert weak estrogen-like effects in the body, potentially alleviating symptoms associated with declining estrogen levels during menopause.

Several randomized controlled trials (RCTs) and systematic reviews have examined red clover’s effectiveness for hot flashes. Some studies suggest a moderate reduction in the frequency and severity of hot flashes in menopausal women supplementing with red clover isoflavones compared to placebo. However, the results are mixed; other trials show minimal or no significant benefit. Meta-analyses generally conclude that while red clover may offer some relief, its effects are relatively modest and not as pronounced as those of hormone replacement therapy (HRT).

Overall, the scientific evidence supporting red clover for hot flashes is limited and inconsistent, with most authorities rating the quality of evidence as low to moderate. Red clover is considered safe for most women when used short-term, but long-term safety has not been well established. In summary, red clover is used based on scientific rationale, but its clinical effectiveness for hot flashes is only modestly supported by current research.

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