Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Isoflavones, particularly those derived from soy, are commonly used to manage hot flashes associated with menopause. The rationale is based on their structural similarity to estrogen, allowing them to weakly bind to estrogen receptors and exert mild estrogenic or anti-estrogenic effects. Several randomized controlled trials and meta-analyses have evaluated the efficacy of isoflavones for hot flashes. Some studies report modest reductions in frequency and severity of hot flashes compared to placebo, especially in women with frequent symptoms. A 2012 Cochrane review concluded that soy isoflavones may reduce the frequency of hot flashes by about 20% compared to placebo, though effects are generally small and not consistently observed across all studies. The evidence base is complicated by variability in isoflavone source, dose, and participant characteristics. Guidelines from organizations such as the North American Menopause Society suggest that soy isoflavones may be considered for women who prefer non-hormonal options, but highlight that the overall benefit is modest and not all women respond. In summary, there is scientific evidence—though not robust—for isoflavones in managing hot flashes, justifying their use in some cases, but expectations should be tempered regarding the magnitude of benefit.

More about Isoflavones (unspecified)
More about Hot Flashes

Other ingredients used for Hot Flashes

Other health conditions supported by Isoflavones (unspecified)

Products containing Isoflavones (unspecified)