Evidence supporting the use of: Vitamin E (not specified)
For the health condition: Hepatitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E has been investigated for its potential role in supporting or treating hepatitis, particularly nonalcoholic steatohepatitis (NASH), a type of non-viral hepatitis. The scientific rationale is based on Vitamin E’s antioxidant properties, which may help counteract oxidative stress implicated in liver inflammation and damage. Several clinical trials, most notably the PIVENS trial (Sanyal et al., 2010, NEJM), have shown that Vitamin E supplementation (typically 800 IU/day) can improve liver histology in non-diabetic adults with NASH. Improvements were seen in liver enzymes, steatosis, and lobular inflammation, although no benefit was observed for fibrosis. Based on such data, some guidelines (e.g., AASLD) cautiously recommend Vitamin E for non-diabetic adults with biopsy-proven NASH. However, evidence is limited or lacking for other forms of hepatitis, such as viral hepatitis (hepatitis B or C), and there are concerns about long-term safety at high doses of Vitamin E. There is little evidence for traditional use of Vitamin E in hepatitis, as its application has emerged primarily from modern research. Overall, while there is some scientific justification—mainly for specific subtypes of hepatitis—the evidence is moderate and does not support broad use for all hepatitis patients.

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