Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (natural tocopherols) has been studied for its potential role in the management of hepatitis, particularly in non-alcoholic steatohepatitis (NASH), a form of non-alcoholic fatty liver disease (NAFLD). The scientific rationale is based on Vitamin E's antioxidant properties, which may help reduce oxidative stress and liver inflammation—key factors in the progression of liver diseases including hepatitis. Several randomized controlled trials, such as the PIVENS trial (Sanyal et al., 2010, NEJM), have demonstrated that Vitamin E supplementation (800 IU/day) can improve liver histology in non-diabetic adults with NASH.

However, evidence for the use of Vitamin E in viral hepatitis (such as Hepatitis B or C) is limited and inconsistent. Some small studies have suggested minor benefits in biochemical markers, but larger, well-controlled trials have not confirmed a significant therapeutic effect. The American Association for the Study of Liver Diseases (AASLD) recommends Vitamin E as an option for non-diabetic adults with biopsy-proven NASH, but not for viral hepatitis.

In summary, while there is scientific evidence supporting Vitamin E’s use in certain types of hepatitis (notably NASH), its efficacy in viral hepatitis is not well established. Overall, the evidence is moderate for NASH (score 2/5) but weak or absent for other forms of hepatitis.

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