Evidence supporting the use of: Vitamin E (Mixed Tocopherols and Tocotrienols)
For the health condition: Hepatitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (including mixed tocopherols and tocotrienols) has some scientific evidence supporting its use as an adjunct therapy in certain types of hepatitis, particularly nonalcoholic steatohepatitis (NASH), a form of nonalcoholic fatty liver disease (NAFLD). Several randomized controlled trials, such as the PIVENS trial (NEJM, 2010), have demonstrated that high-dose vitamin E supplementation (typically 800 IU/day of alpha-tocopherol) can improve liver histology in non-diabetic adults with NASH, reducing steatosis, inflammation, and hepatocellular ballooning. The presumed mechanism involves vitamin E’s antioxidant properties, mitigating oxidative stress believed to contribute to liver injury in NASH. However, the evidence for vitamin E use in viral hepatitis (e.g., hepatitis B or C) is limited and inconclusive. Some small studies have investigated its role in these conditions, but results do not consistently show significant benefit, and it is not a standard therapy for viral hepatitis. Safety concerns about long-term high-dose vitamin E supplementation, such as increased risk of hemorrhagic stroke or prostate cancer, have also been raised. In summary, vitamin E is scientifically validated as a supportive treatment for NASH in select populations, but not for all forms of hepatitis, and the overall strength of evidence is moderate.

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