Evidence supporting the use of: Vitamin E (mixed tocopherols)
For the health condition: Hepatitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (mixed tocopherols) has some scientific evidence supporting its use in the context of hepatitis, particularly non-alcoholic steatohepatitis (NASH), a form of non-alcoholic fatty liver disease (NAFLD). Vitamin E is a potent lipid-soluble antioxidant, and oxidative stress is thought to play a role in the pathogenesis of various types of hepatitis, especially NASH. Several randomized controlled trials, including the PIVENS trial (published in the New England Journal of Medicine, 2010), found that high-dose Vitamin E (800 IU daily) improved liver histology in non-diabetic adults with NASH compared to placebo. However, evidence for Vitamin E’s benefit in other forms of hepatitis, such as viral hepatitis (hepatitis B or C), is limited and inconclusive. Some small studies have explored its antioxidant effects in chronic hepatitis C but showed minimal or no improvement in liver function or viral load. Clinical guidelines (such as those from the American Association for the Study of Liver Diseases) recommend Vitamin E only in selected non-diabetic adults with biopsy-proven NASH and do not support its widespread use for other hepatitis types. In summary, there is moderate quality scientific evidence for Vitamin E's use in NASH, but not for other forms of hepatitis.

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