Evidence supporting the use of: Vitamin E (mixed)
For the health condition: Hepatitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E, particularly in its mixed tocopherol forms, has been investigated for its role in supporting or treating hepatitis, especially non-alcoholic steatohepatitis (NASH), a form of non-alcoholic fatty liver disease (NAFLD). The rationale is based on its antioxidant properties, as oxidative stress is believed to play a role in the pathogenesis of hepatitis and liver injury. Several clinical studies, including randomized controlled trials, have shown that vitamin E supplementation (usually at a dose of 800 IU/day of alpha-tocopherol) can improve liver histology and biochemical markers in adults and children with NASH who do not have diabetes. The PIVENS trial (Sanyal et al., 2010, NEJM) is a key study showing that vitamin E improved steatosis, inflammation, and ballooning in biopsy-proven NASH compared to placebo. However, evidence for its use in viral hepatitis (such as hepatitis B or C) is lacking, and it is not considered a standard treatment for these forms. Additionally, concerns remain about long-term high-dose vitamin E supplementation and potential adverse outcomes, including increased all-cause mortality or risk of hemorrhagic stroke in some populations. In summary, there is moderate scientific evidence for the use of vitamin E in treating NASH, but not for other forms of hepatitis, and it is not universally recommended.

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