Evidence supporting the use of: Vitamin E (alpha-tocopheryl hydrochloride)
For the health condition: Hepatitis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E, specifically in its alpha-tocopherol form, has been investigated for its role in supporting or treating hepatitis, particularly nonalcoholic steatohepatitis (NASH), a severe form of nonalcoholic fatty liver disease (NAFLD). The rationale for its use is based on its antioxidant properties, which may help counteract the oxidative stress implicated in the progression of liver inflammation and fibrosis. Several randomized controlled trials, including the PIVENS trial published in the New England Journal of Medicine (2010), have shown that high-dose vitamin E (800 IU/day) can improve liver histology in non-diabetic adults with NASH, decreasing steatosis, inflammation, and hepatocellular ballooning. These findings led to the American Association for the Study of Liver Diseases (AASLD) recommending vitamin E as an option for non-diabetic adults with biopsy-proven NASH. However, evidence for its use in viral hepatitis (like hepatitis B or C) is much weaker and not routinely recommended. The form “alpha-tocopheryl hydrochloride” specifically is not commonly referenced in major studies or guidelines, as most research uses alpha-tocopherol or alpha-tocopheryl acetate. Overall, while there is scientific evidence supporting vitamin E use in select hepatitis subtypes (mainly NASH), the strength of evidence is moderate and not generalized to all forms of hepatitis.

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