Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Sesquiterpenes are a class of naturally occurring compounds found in many plants, including medicinal herbs such as Artemisia capillaris and Curcuma longa (turmeric). Some sesquiterpene derivatives, such as artemisinin and its analogs, have been studied for their hepatoprotective and antiviral effects, particularly in the context of hepatitis. Laboratory and animal studies suggest that certain sesquiterpenes may exert anti-inflammatory, antioxidant, and antiviral activities that could theoretically benefit liver function and reduce liver injury caused by hepatitis viruses. For example, artemisinin-type sesquiterpenes have exhibited inhibitory effects against hepatitis B virus (HBV) replication in vitro. Additionally, some sesquiterpene lactones have been shown to modulate immune responses and attenuate liver fibrosis in animal models.

However, clinical evidence in humans remains limited and preliminary. Most studies to date are either in vitro (cell culture) or in vivo (animal) experiments, with only a few small-scale or pilot clinical trials. These trials often lack rigorous controls or sufficient sample sizes to draw strong conclusions. Therefore, while there is a scientific rationale and some early-stage evidence supporting the potential use of sesquiterpenes in hepatitis, their efficacy and safety for this indication are not yet well-established, and more robust clinical research is required.

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