Polygonatum species, commonly known as Solomon's Seal, have a long history of use in traditional Chinese medicine (TCM) and other East Asian medical systems. Within TCM, Polygonatum (notably Polygonatum sibiricum and Polygonatum odoratum) is primarily considered a tonic herb, used to nourish yin, moisten dryness, and support lung and kidney function. Its use for liver-related conditions, including hepatitis, is largely based on its general restorative and tonic effects, rather than specific antiviral activity or hepatoprotective mechanisms documented in scientific literature.

There are anecdotal reports and some traditional herbal formulas that combine Polygonatum with other herbs for conditions interpreted as "liver heat" or "chronic weakness," which, in modern terms, could overlap with hepatitis. However, direct evidence—either from historical sources specifically citing hepatitis or from robust modern clinical research—is lacking. Most available scientific studies focus on Polygonatum’s antioxidant, immunomodulatory, or anti-inflammatory properties, often in vitro or animal models, but do not establish its efficacy or safety for hepatitis in humans.

In summary, while Polygonatum is sometimes included in traditional herbal formulas used to address symptoms potentially related to hepatitis, there is minimal traditional specificity and little to no scientific evidence directly supporting its use for this condition. Its application is thus justified primarily by tradition, not scientific validation.