Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phenolic diterpenes, such as carnosic acid and carnosol, are naturally occurring compounds found in plants like rosemary (Rosmarinus officinalis) and sage (Salvia officinalis). Their use to support or treat hepatitis is primarily based on preclinical scientific studies rather than traditional medicine practices. Several in vitro and animal studies have demonstrated that these compounds possess antioxidant and anti-inflammatory properties that may protect liver cells from damage. For instance, carnosic acid has shown hepatoprotective effects in models of chemically induced liver injury, likely due to its ability to modulate oxidative stress and inflammation pathways. Some studies have also reported that phenolic diterpenes can inhibit the replication of hepatitis viruses in cell cultures. However, there is a lack of robust human clinical trials directly examining the efficacy of phenolic diterpenes in hepatitis patients. Most of the evidence comes from laboratory and animal research, which does not always translate to clinical effectiveness in humans. Therefore, while there is a scientific rationale for their potential benefit, current evidence is limited and insufficient to recommend phenolic diterpenes as a primary treatment for hepatitis. Further human studies are needed to establish safety, efficacy, and appropriate dosing.

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