Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactoferrin, an iron-binding glycoprotein found in milk and other secretions, has been investigated for its potential to support or treat hepatitis, particularly hepatitis C virus (HCV) infection. Several in vitro and animal studies have demonstrated that lactoferrin can inhibit the replication of various viruses, including HCV, through mechanisms such as blocking viral attachment and entry into host cells, modulating immune responses, and exerting anti-inflammatory effects. Some early clinical trials in the early 2000s evaluated oral bovine lactoferrin as an adjunct to standard therapy for chronic hepatitis C. These studies showed mild reductions in viral load and improvements in liver enzyme levels, but the effects were generally modest and inconsistent. Meta-analyses and systematic reviews have concluded that while lactoferrin appears safe and may have a mild antiviral effect, the overall quality and quantity of evidence are low, and it cannot be recommended as a primary or stand-alone treatment for hepatitis C or other forms of hepatitis. Most clinical guidelines do not mention lactoferrin as a therapeutic option. Thus, while there is some scientific investigation and preliminary evidence, the support is weak, and lactoferrin is not an established treatment for hepatitis.

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