Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B3, in the form of nicotinamide (and its precursor, niacin), has a scientifically supported role in hepatic (liver) function, primarily due to its involvement in key metabolic pathways. Nicotinamide is a precursor to NAD⁺ and NADP⁺, essential coenzymes in redox reactions that are crucial for cellular energy production, detoxification, and repair in hepatocytes (liver cells). Deficiency in vitamin B3 can lead to pellagra, which, among other symptoms, can include liver dysfunction.

Beyond deficiency states, some clinical studies and preclinical research have explored the use of nicotinamide in preventing or ameliorating liver diseases. For example, both niacin and nicotinamide have been studied for their ability to improve hepatic steatosis (fatty liver) and reduce inflammation in non-alcoholic fatty liver disease (NAFLD) models, attributed to their effects on lipid metabolism and anti-inflammatory properties. However, while there are positive findings, the evidence remains moderate, and the use of nicotinamide specifically for liver disease prevention or treatment is not yet established in clinical guidelines. In contrast, high doses of niacin (not nicotinamide) have been associated with hepatotoxicity, cautioning against unsupervised supplementation.

In summary, there is scientific rationale and some supporting evidence for the use of vitamin B3 (nicotinamide) in supporting hepatic function, particularly in the context of deficiency and metabolic support, though robust clinical recommendations for its use in specific liver diseases are still lacking.

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