Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B2 (Riboflavin) plays a key role in the hepatic (liver) system primarily due to its function as a precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). These coenzymes are essential for numerous oxidation-reduction (redox) reactions in metabolic pathways, including those involved in the liver’s detoxification processes and energy production. Riboflavin is required for the proper functioning of cytochrome P450 enzymes, which are heavily involved in drug metabolism and the breakdown of toxins in the liver. Deficiency in riboflavin can impair these processes, leading to hepatic dysfunction and inflammation, as observed in animal models and some human studies.

Several clinical and preclinical studies have demonstrated that adequate riboflavin status supports normal liver function and may protect against certain forms of liver damage, such as that induced by oxidative stress. However, while riboflavin is essential for liver health, there is limited evidence that supplementation beyond recommended dietary allowances confers additional hepatic benefits in otherwise healthy individuals. The use of riboflavin in liver support is scientifically validated primarily in the context of deficiency or increased metabolic demand. Overall, the evidence supports a foundational role for riboflavin in hepatic function, but not necessarily for therapeutic supplementation in liver diseases outside of deficiency states.

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