Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Terpenoids, also known as isoprenoids, are a large and diverse class of naturally occurring organic chemicals derived from five-carbon isoprene units. They are found in many plants and are known for their aromatic properties and roles in traditional medicine. There is a growing body of scientific evidence supporting the use of certain terpenoids to support the hepatic (liver) system. Several studies have investigated the hepatoprotective effects of terpenoids such as silymarin (from milk thistle, Silybum marianum), glycyrrhizin (from licorice root), and curcumin (from turmeric), among others. These compounds exhibit antioxidant, anti-inflammatory, and anti-fibrotic properties that can protect liver cells from damage caused by toxins, drugs, and diseases such as hepatitis. For instance, silymarin has been shown in clinical and preclinical studies to reduce liver enzyme levels and improve liver function in cases of hepatitis and cirrhosis. Similarly, glycyrrhizin has demonstrated efficacy in reducing liver inflammation and fibrosis in chronic hepatitis patients. However, while the collective evidence for terpenoids as a broad class is promising, the strength and quality of evidence can vary significantly between individual compounds, and large-scale human trials are limited for many terpenoids. Overall, the use of select terpenoids for hepatic support is scientifically substantiated, though further research is warranted to clarify mechanisms and long-term benefits.

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